It's very difficult to choose just one due to all the variables involved. Some of the very best telescopes that I've used include a friend's 7" f/13.4 Questar Titanium Maksutov-Cassegrain, a friend's 206mm f/7.9 Astro-Physics Starfire apochromatic refractor (Roland Christen made only a handful of the 8" Starfires - the OTAs, which originally cost $12,500, fetch incredible sums nowadays on the used market), a 10" APM (?) achromatic refractor with a Chromacor, several Mag 1 Instrument Portaball Newtonians (8, 10, and 12.5"), an 11" D & G Optical achromat, the 20" f/10 classical Cassegrain previously mentioned, the 24" achromatic refractors at the Sproul Observatory and the Lowell Observatory, a friend's 32" f/4 ATM goto Dob, and Tom Clark's original 36" f/5 Yard Scope. (I once had a look through a 36" Obsession but the conditions weren't too good and the owner was using an eyepiece that produced far too large an exit pupil.)
Other notable telescopes that I've observed with include a few 6 and 7.1" A-P apochromats, a 6" Takahashi apochromat, an 8" f/15 D & G Optical achromat, an 8" f/9 APM achromat, a number of excellent Starmaster (14.5, 20 and 24") and Obsession (15, 18, 20, and 25") Dobs, a 22" Telekit Dob, two 28" Dobs, and several 30" Dobs (one being a Tectron and the other two ATMs). I've also used many optically excellent ATM telescopes including Tri-Schieflspiegler reflectors, a Gregorian reflector, Herschelian reflectors, a Ritchey-Chretien Cassegrain, and other oddball designs at Stellafane over the years.
If I had to choose one small rich-field telescope it would be a 127mm f/5.2 Tele Vue-NP127is, one large apochromatic refractor it would be a used 206mm f/7.9 A-P Starfire or perhaps a 229mm f/9 TMB, one small Newtonian it would be a 10" Portaball, one small MNT it would be a used 5.7" f/6.5 HD-145 Peter Ceravolo Maksutov-Newtonian, one large MCT it would be a used 10" f/14.6 Astro-Physics High-Resolution Maksutov-Cassegrain, and one large Dobsonian it would be a 20" f/3.7 Starmaster Sky Tracker Dob.
Alright, if I had to choose one favorite scope in terms of adequate aperture and ease of use (without imaging in mind) it would be a 12.5" f/5 Portaball.
Dave Mitsky